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One of the most important problems discussed recently in structural engineering is the structural reliability analysis considering uncertainties. To have an efficient optimization process for designing a safe structure, firstly it is required to study the effects of uncertainties on the seismic performance of structure and then incorporate these effects on the optimization process. In this study, a new procedure developed for incorporating two important sources of uncertainties in design optimization process of steel moment resisting frames, is proposed. The first source is related to the connection parameter uncertainties and the second one to seismic demand uncertainty. Additionally Mont Carlo (MC) simulation and a variance reduction technique (VRT) are utilized to deal with uncertainties and to reduce the corresponding computational cost. In the proposed procedure two design objectives are considered, which are structural weight and collapse prevention reliability index for a moment resisting frame in such a way that leads to a set of optimum designs with minimum weight and less possible amounts of sensitivity to connection parameters uncertainties and spectral acceleration uncertainty as seismic demand variation. Additionally, in this procedure the reliability index is computed considering all FEMA-356 performance acceptance criteria, the approach that has never been investigated in other studies. The efficiency of this approach is illustrated by exhibiting a set of optimum designs, in the form of both objective values and investigating nonlinear behavior of optimum designs compared with non-optimum designs. This procedure is introduced in this paper with emphasize on the collapse limit state and applying pushover analysis for studying the nonlinear behavior of structural elements.